Espercil

Espercil may be available in the countries listed below.

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Tranexamic Acid

Tranexamic Acid is reported as an ingredient of Espercil in the following countries:

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Ramigamma HCT

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Hydrochlorothiazide

Hydrochlorothiazide is reported as an ingredient of Ramigamma HCT in the following countries:

• Germany

Ramipril

Ramipril is reported as an ingredient of Ramigamma HCT in the following countries:

• Germany

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Acyclovir

Aciclovir is reported as an ingredient of Lovire in the following countries:

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Cefaclor

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Morphine

Morphine hydrochloride (a derivative of Morphine) is reported as an ingredient of Morphin HCl Amino in the following countries:

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Moapar

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Triptorelin

Triptorelin embonate (a derivative of Triptorelin) is reported as an ingredient of Moapar in the following countries:

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Minocycline

Minocycline hydrochloride (a derivative of Minocycline) is reported as an ingredient of Pardoclin in the following countries:

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Somatostatin

Somatostatin x acetate (a derivative of Somatostatin) is reported as an ingredient of Modustatina in the following countries:

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Mebhydrolin

Mebidrolina (DCIT) is also known as Mebhydrolin (Rec.INN)

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Cytodrox

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Hydroxycarbamide

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Mebeverine

Mebeverine hydrochloride (a derivative of Mebeverine) is reported as an ingredient of Mebeverin Solvay in the following countries:

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Digoxin

Digoxin is reported as an ingredient of Eudigox in the following countries:

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Meloxicam Tetrafarma

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Meloxicam

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Finaplix

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Trenbolone

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Rythmodan Capsules

1. Name Of The Medicinal Product

Rythmodan 100mg Capsules.

Rythmodan 150mg Capsules.

2. Qualitative And Quantitative Composition

Capsule containing Disopyramide 100mg.

Capsule containing Disopyramide 150mg.

For excipients, see section 6.1.

3. Pharmaceutical Form

Capsule.

4. Clinical Particulars

4.1 Therapeutic Indications

Rythmodan is used in the treatment of cardiac arrhythmias as follows:-

1. The prevention and treatment of arrhythmias occurring after myocardial infarction.

2. Maintenance of normal rhythm following electroconversion eg atrial fibrillation, atrial flutter.

3. Persistent ventricular extrasystoles.

4. Control of arrhythmias following the use of digitalis or similar glycosides.

5. Suppression of arrhythmias during surgical procedures eg cardiac catheterisation.

6. The prevention of paraxysmal supraventricular tachycardia.

7. Other types of arrhythmias e.g. atrial extrasystoles, Wolff-Parkinson-White Syndrome.

4.2 Posology And Method Of Administration

Route of administration

Oral

300 mg to 800mg daily in divided doses.

Children :

Not recommended as insufficient data available.

Elderly

A dose reduction due to reduced renal and hepatic function in the elderly (especially elderly non-smokers) should be considered (see section 4.4)

4.3 Contraindications

Disopyramide is contra–indicated in un–paced second or third degree atrioventricular block; bundle–branch block associated with first–degree atrioventricular block ; unpaced bifascicular block; pre-existing long QT syndromes; severe sinus node dysfunction ; severe heart failure, unless of secondary to cardiac arrhythmia ; hypersensitivity to disopyramide. It is also contra–indicated in concomitant administration with other anti–arrhythmics or other drugs liable to provoke ventricular arrhythmias, especially Torsade de Pointes (see section 4.5). The sustained release formulation is contra–indicated in patients with renal or hepatic impairment.

4.4 Special Warnings And Precautions For Use

Antiarrhythmic drugs belonging to the class 1c (Vaughan Williams Classification) were included in the Cardiac Arrhythmia Suppression Trial (CAST), a long term multicentre randomised, double blind study in patients with asymptomatic non life–threatening ventricular arrhythmia who have had a myocardial infarction more than six days but less than two years previously. A significant increase in mortality and non–fatal cardiac arrest rate was seen in patients treated with class 1c antiarrhythmic drugs when compared with a matched placebo group. The applicability of the CAST results to other antiarrhythmics and other populations (eg. those without recent infarction) is uncertain. At present, it is best to assume that the risk extends to other antiarrhythmic agents for patients with structural heart disease.

There is no evidence that prolonged suppression of ventricular premature contractions with antiarrhythmic drugs prevents sudden death. For this reason, antiarrhythmic drugs should not be prescribed for the treatment of patients with asymptomatic ventricular premature contractions.

All antiarrhythmic drugs can produce unwanted effects when they are used to treat symptomatic but not life threatening arrhythmia; the expected benefits should be balanced against their risks.

In patients with structural heart disease, proarrhythmia and cardiac decompensation are special risks associated with antiarrhythmic drugs. Special caution should be exercised when prescribing in this context.

Disopyramide should not be used in patients with uncompensated congestive heart failure, unless this heart failure is secondary to cardiac arrhythmia. If disopyramide is to be given under these circumstances, special care and monitoring are essential.

Life-threatening and haemodynamically significant arrhythmias are difficult to treat and affected patients have a high mortality risk. Treatment of these arrhythmias, by whatever modality, must be initiated in hospital.

Owing to its negative inotropic effect, disopyramide should be used with caution in patients suffering from significant cardiac failure.This group may be specially sensitive to the negative inotropic properties of disopyramide. Such patients should be fully digitalised or controlled with other therapy before treatment with disopyramide is commenced.

Aggravation of existing arrhythmia, or emergence of a new type of arrhythmia, demands urgent review of disopyramide treatment.

Similarly, if an atrioventricular block or a bifascicular block occurs during treatment, the use of disopyramide should be reviewed.

There have been reports of ventricular tachycardia, ventricular fibrillation and Torsade de Pointes in patients receiving disopyramide. These have usually, but not always, been associated with significant widening of the QRS complex or prolonged QT interval. The QT interval and QRS duration must be monitored and disopyramide should be stopped if these are increased by more than 25%. If these changes or arrhythmias develop the drug should be discontinued. Disopyramide should be used only with caution in patients with atrial flutter or atrial tachycardia with block as conversion of a partial AV block to a 1:1 response may occur, leading to a potentially more serious tachyarrhythmia.

The occurrence of hypotension following disopyramide administration requires prompt discontinuation of the drug. This has been observed especially in patients with cardiomyopathy or uncompensated congestive heart failure. Any resumption of therapy should be at a lower dose with close patient monitoring. Disopyramide should be used with caution in the treatment of digitalis intoxication.

Potassium imbalance: Antiarrhythmic drugs may be hazardous in patients with potassium imbalance, as potassium abnormalities can induce arrhythmias.

During treatment with disopyramide, potassium levels should be checked regularly. Patients treated with diuretics or stimulant laxatives are at particular risk of hypokalaemia.

Renal insufficiency: In renal insufficiency, the dosage of disopyramide should be reduced by adjusting the interval between administrations.

Hepatic insufficiency: Hepatic impairment causes an increase in the plasma half–life of Rythmodan and a reduced dosage may be required.

Hypoglycaemia: Hypoglycaemia has been reported in association with disopyramide administration. The risk of hypoglycaemia, sometimes severe, occurs particularly in elderly or malnourished subjects, treated diabetics and patients with renal insufficiency or cardiac failure. Blood sugar levels should be monitored in all patients. Strict adherence to the dosing recommendations is advised. If hypoglycaemia occurs then treatment with disopyramide should be stopped.

Hypoglycaemia may be associated with interactions with drugs metabolised by hepatic CYP3A (see Section 4.5 Interactions with other medicinal products and other forms of interaction).

Atropine–like effects : There is a risk of :

– ocular hypertension in patients with narrow–angle glaucoma

– acute urinary retention in patients with prostatic enlargement

– aggravation of myasthenia gravis

– cognitive disorders, especially in elderly patients (see also section 4.8).

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

Combination with other antiarrhythmic drugs : Combinations of antiarrhythmic drugs are not well researched and their effect may be unpredictable. Thus, antiarrhythmic combination should be avoided except under certain circumstances, eg. beta–blockers for angina pectoris ; digoxin with beta–blocker and verapamil for the control of atrial fibrillation, when defined as effective for an individual.

Interaction with drugs associated with risk of Torsade de Pointes, such as

– tricyclic and tetracyclic antidepressants

– All macrolide antibiotics (e.g. erythromycin, clarithromycin, azithromycin etc)

– astemizole ; cisapride ; pentamidine ; pimozide ; sparfloxacin ; terfenadine and thioridazone.

Phosphodiesterase Type 5 Inhibitors:

There is evidence that phosphodiesterase Type 5 inhibitors may be potentially associated with a risk of QT prolongation. Concomitant administration of disopyramide with such drugs may potentially enhance this QT prolongation effect and is not recommended.

The concomitant use of these medications whilst undergoing treatment with disopyramide increases the chance of cardiac arrhythmia.

There is some evidence that disopyramide is metabolised by hepatic CYP3A. Concomitant administration of significant inhibitors of this isozyme (e.g. certain macrolide or azole antifungal antibiotics) may therefore increase the serum levels of disopyramide. On the other hand, inducers of CYP3A (e.g. rifampicin and certain anticonvulsants such as phenytoin, primidone and phenobarbital) may reduce disopyramide and increase MN–disopyramide serum levels. Since the magnitude of such potential effects is not foreseeable, such drug combinations are not recommended.

When prescribing a drug metabolised by CYP3A [such as theophylline, HIV protease inhibitors (e.g. ritonavir, indinavir, saquinavir), ciclosporin A, warfarin] it should be kept in mind that disopyramide is probably also a substrate of this isozyme and thus competitive inhibition of metabolism might occur, possibly increasing serum levels of these drugs.

Interactions with hypokalaemia inducing drugs : Concomitant use with drugs can induce hypokalaemia such as : diuretics, amphotericin B, tetracosactide (corticotropin analogue), gluco and mineralo–corticoids may reduce the action of the drug, or potentiate proarrhythmic effects. Stimulant laxatives are not recommended to be given concomitantly, due to their potassium lowering potential.

Other drug interactions :

Atropine and other anticholinergic drugs, including phenothiazines, may potentiate the atropine–like effects of disopyramide.

4.6 Pregnancy And Lactation

Pregnancy: Although Rythmodan has undergone animal tests for teratogenicity without evidence of any effect on the developing foetus, its safety in human pregnancy has not been established. Rythmodan has been reported to stimulate contractions of the pregnant uterus. The drug should only be used during pregnancy if benefits clearly outweigh the possible risks to the mother and foetus.

Lactation: Studies have shown that oral Rythmodan is secreted in breast milk, although no adverse effects to the infant have been noted. However, clinical experience is limited and Rythmodan should only be used in lactation if, in the clinician's judgement, it is essential for the welfare of the patient. The infant should be closely supervised, particularly for anticholinergic effects and drug levels determined if necessary. Ideally, if the drug is considered essential, an alternative method of feeding should be used.

4.7 Effects On Ability To Drive And Use Machines

Some adverse reactions may impair the patients ability to concentrate and react, and hence the ability to drive or operate machinery. (See section 4.8).

4.8 Undesirable Effects

Cardiac: It is accepted that the arrhythmogenic potential of disopyramide is weak. However, as with all antiarrhythmic drugs, disopyramide may worsen or provoke arrhythmias. This proarrhythmic effect is more likely to occur in the presence of hypokalemia with the associated use of antiarrhythmic drugs, in patients with severe structural heart disease with prolongation of the QT interval.

Intra–cardiac conduction abnormalities may occur: QT interval prolongation, widening of the QRS complex, atrioventricular block and bundle–branch block.

Other types of arrhythmia have been reported: Bradycardia, sinus block, ventricular fibrillation, ventricular tachycardia and torsades de pointes.

Episodes of severe heart failure or even cardiogenic shock have also been described particularly in patients with severe structural heart disease. The resulting low cardiac output can cause hypotension, renal insufficiency and/or acute hepatic ischemia.

Other adverse reactions include:

Atropine-like effects (see also section 4.4):

	urinary: dysuria; acute urinary retention, especially in prostatism
	ocular: disorders of accommodation; diplopia
	gastrointestinal: dry mouth; abdominal pain; nausea, vomiting, anorexia, diarrhoea; constipation
	impotence
	cognitive disorders

Psychiatric disorders.

Skin reactions: very rarely, rashes.

Rarely: hypoglycaemia, sometimes severe (see Section 4.4 Special warnings and precautions for use). In some cases, severe hypoglycaemia resulted in coma.

Very rarely: cholestatic jaundice, headache, dizzy sensation, neutropenia.

4.9 Overdose

There is no specific antidote for disopyramide. Prostigmine derivatives can be used to treat anticholinergic effects. Symptomatic supportive measures may include : early gastric lavage ; administration of a cathartic followed by activated charcoal by mouth or stomach tube ; IV administration of isoprenaline, other vasopressors and/or positive inotropic agents ; if needed - infusion of lactate and/or magnesium, electro–systolic assistance, cardioversion, insertion of an intra–aortic balloon for counterpulsion and mechanically assisted ventilation. Haemodialysis, haemofiltration or haemoperfusion with activated charcoal has been employed to lower the serum concentrations of the drug.

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

Class 1 anti-arrhythmic agent.

It decreases membrane responsiveness, prolongs the effective refractory period (ERP) and slows automaticity in cells with augmented automaticity. Effective refractory period of the atrium is lengthened, ERP of the A-V node is shortened and conduction in accessory pathways is prolonged.

Disopyramide is a myocardial depressant and has anti-cholinergic effects.

5.2 Pharmacokinetic Properties

Elimination phase of plasma t1/2 : 5-8 hours. Increased in hepatic impairment, cardiac and hepatic disease.

Protein binding: 50 - 60%. Saturable and concentration dependent.

Volume of distribution: Variable according to method of determination.

Metabolism: Approximately 25% of a dose metabolised to a mono-N-dealkylated derivative. Additional 10% as other metabolites.

Excretion: 75% unchanged drug via urine, remainder in faeces mono-N-dealkylated metabolite 25% in urine, 64% via faeces.

5.3 Preclinical Safety Data

Not applicable.

6. Pharmaceutical Particulars

6.1 List Of Excipients

Maize starch

Magnesium stearate

STA-RX 1500 (pregelatinised starch)

Talc.

Capsule shell:

Gelatin

Indigo carmine,

Iron oxide and

Titanium dioxide (E171)

6.2 Incompatibilities

Not known.

6.3 Shelf Life

PVC Blister: 36 months

6.4 Special Precautions For Storage

Do not store above 25^oC

6.5 Nature And Contents Of Container

PVC/PVdC blister strips in cardboard cartons containing 84 capsules.

6.6 Special Precautions For Disposal And Other Handling

None.

7. Marketing Authorisation Holder

Sanofi-aventis

One Onslow Street

Guildford

Surrey

GU1 4YS

8. Marketing Authorisation Number(S)

Rythmodan 100mg capsules: PL 04425/0607

Rythmodan 150mg capsules: PL 04425/0608

9. Date Of First Authorisation/Renewal Of The Authorisation

12 February 2009

10. Date Of Revision Of The Text

24 February 2010

Legal Category: POM

Bisoprolol HCT Sandoz

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Bisoprolol

Bisoprolol fumarate (a derivative of Bisoprolol) is reported as an ingredient of Bisoprolol HCT Sandoz in the following countries:

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Hydrochlorothiazide is reported as an ingredient of Bisoprolol HCT Sandoz in the following countries:

• Germany

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Nadroparin Calcium

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Ketotifen

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Modula

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Polycarbophil

Polycarbophil calcium salt (a derivative of Polycarbophil) is reported as an ingredient of Modula in the following countries:

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Metronidazole

Metronidazole is reported as an ingredient of Bactrizol in the following countries:

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Trimethoprim

Trimethoprim is reported as an ingredient of Bactrizol in the following countries:

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Planor

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Fluoxetine

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Erythromycin

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Cortef

In the US, Cortef (hydrocortisone systemic) is a member of the drug class glucocorticoids and is used to treat Addison's Disease, Adrenocortical Insufficiency, Asthma - acute, Inflammatory Conditions and Shock.

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Hydrocortisone

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Methaniazide

Scheme

Rec.INN

CAS registry number (Chemical Abstracts Service)

0013447-95-5

Chemical Formula

C7-H9-N3-O4-S

Molecular Weight

231

Therapeutic Category

Antitubercular agent

Chemical Name

4-Pyridinecarboxylic acid, 2-(sulfomethyl)hydrazide

Foreign Names

• Methaniazidum (Latin)
• Methaniazid (German)
• Méthaniazide (French)
• Metaniazida (Spanish)

Generic Names

• Metaniazide (OS: DCIT)
• Isoniazid methanesulfonate (IS)
• Isoniazide Sodium Methanesulfonate (OS: JAN)

Brand Name

• Neoiscotin
  Daiichi Sankyo, Japan

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Glossary

DCIT	Denominazione Comune Italiana
IS	Inofficial Synonym
JAN	Japanese Accepted Name
OS	Official Synonym
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)

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Isosorbide mononitraat Mylan

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Biosporin

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Ciclosporin

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Pentoxifylline

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• Russian Federation

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Ciflot

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Ciprofloxacin

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Pertussin

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Dextromethorphan

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Calcium Folinate

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• Luxembourg

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Faktor IX "SSI&quot

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Coagulation Factor IX, Human

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Acexamic Acid

Scheme

Rec.INN

CAS registry number (Chemical Abstracts Service)

0000057-08-9

Chemical Formula

C8-H15-N-O3

Molecular Weight

173

Therapeutic Categories

Dermatological agent

Wound healing agent

Chemical Name

Hexanoic acid, 6-(acetylamino)-

Foreign Names

• Acidum Acexamicum (Latin)
• Acexaminsäure (German)
• Acide acexamique (French)
• Acido acexamico (Spanish)

Generic Names

• Acexamic Acid (OS: BAN)
• Acide acexamique (OS: DCF)
• Acide acexamicum (IS)
• CY 153A (IS)
• Zinc Acexamate (OS: BANM)
• Zinc (Acéxamatd de) (PH: Ph. Eur. 6)
• Zinc Acexamate (PH: BP 2010, Ph. Eur. 6)
• Zinci acexamas (PH: Ph. Eur. 6)
• Zinkacexamat (PH: Ph. Eur. 6)

Brand Names

• Plastesol
  CPH, Portugal



• Recoveron
  Armstrong, Mexico



• Acido acexamico Austral
  Austral, Argentina



• Plastenan
  Eumedica, Luxembourg; Johnson & Johnson, France; Sanofi-Aventis, Argentina



• Recoveron
  Armstrong, Costa Rica; Armstrong, Dominican Republic; Armstrong, Guatemala; Armstrong, Honduras; Armstrong, Mexico; Armstrong, Nicaragua; Armstrong, El Salvador



• Restaurene
  Ivax, Argentina



• Copinal
  Viñas, Spain

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Glossary

BAN	British Approved Name
BANM	British Approved Name (Modified)
DCF	Dénomination Commune Française
IS	Inofficial Synonym
OS	Official Synonym
PH	Pharmacopoeia Name
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)

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Groprim

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Sulfamethoxazole

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• Bahrain


• Ethiopia


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Trimethoprim

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• Bahrain


• Ethiopia


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L-Carn

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Levocarnitine

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• Germany

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Tamsulosin Hydrochlorid Actavis

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Tamsulosin

Tamsulosin hydrochloride (a derivative of Tamsulosin) is reported as an ingredient of Tamsulosin Hydrochlorid Actavis in the following countries:

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Asenapine maleate

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Asenapine

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Glossary

USAN	United States Adopted Name

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Fluoxetin AbZ

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Fluoxetine

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• Germany

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Tylobel

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In some countries, this medicine may only be approved for veterinary use.

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Tylosin

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Trimebutine

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Buprénorphine Biogaran

Buprénorphine Biogaran may be available in the countries listed below.

Ingredient matches for Buprénorphine Biogaran

Buprenorphine

Buprenorphine hydrochloride (a derivative of Buprenorphine) is reported as an ingredient of Buprénorphine Biogaran in the following countries:

• France

International Drug Name Search

Palovir

Palovir may be available in the countries listed below.

Ingredient matches for Palovir

Acyclovir

Aciclovir is reported as an ingredient of Palovir in the following countries:

• Indonesia

International Drug Name Search

Iconal

Iconal may be available in the countries listed below.

Ingredient matches for Iconal

Meloxicam

Meloxicam is reported as an ingredient of Iconal in the following countries:

• Greece

International Drug Name Search

Fluress

In the US, Fluress is a member of the drug class ophthalmic diagnostic agents.

Ingredient matches for Fluress

Fluorescein

Fluorescein sodium (a derivative of Fluorescein) is reported as an ingredient of Fluress in the following countries:

• Sweden

Oxybuprocaine

Oxybuprocaine hydrochloride (a derivative of Oxybuprocaine) is reported as an ingredient of Fluress in the following countries:

• Sweden

International Drug Name Search

Risperidon BMM Pharma

Risperidon BMM Pharma may be available in the countries listed below.

Ingredient matches for Risperidon BMM Pharma

Risperidone

Risperidone is reported as an ingredient of Risperidon BMM Pharma in the following countries:

• Sweden

International Drug Name Search

Fluxpiren

Fluxpiren may be available in the countries listed below.

Ingredient matches for Fluxpiren

Diclofenac

Diclofenac sodium salt (a derivative of Diclofenac) is reported as an ingredient of Fluxpiren in the following countries:

• Argentina

International Drug Name Search

Adrenalin Amino

Adrenalin Amino may be available in the countries listed below.

Ingredient matches for Adrenalin Amino

Epinephrine

Epinephrine bitartrate (a derivative of Epinephrine) is reported as an ingredient of Adrenalin Amino in the following countries:

• Switzerland

International Drug Name Search

Isotic Cetride

Isotic Cetride may be available in the countries listed below.

Ingredient matches for Isotic Cetride

Sulfacetamide Sodium

Sulfacetamide sodium salt (a derivative of Sulfacetamide) is reported as an ingredient of Isotic Cetride in the following countries:

• Indonesia

International Drug Name Search

Actrapid HM Penfill

Actrapid HM Penfill may be available in the countries listed below.

Ingredient matches for Actrapid HM Penfill

Insulin Injection, Soluble

Insulin Injection, Soluble human (a derivative of Insulin Injection, Soluble) is reported as an ingredient of Actrapid HM Penfill in the following countries:

• Switzerland

International Drug Name Search

Ipstyl

Ipstyl may be available in the countries listed below.

Ingredient matches for Ipstyl

Lanreotide

Lanreotide is reported as an ingredient of Ipstyl in the following countries:

• Italy

Lanreotide acetate (a derivative of Lanreotide) is reported as an ingredient of Ipstyl in the following countries:

• Denmark


• Iceland


• Italy


• Norway

International Drug Name Search

Mucinum

Mucinum may be available in the countries listed below.

Ingredient matches for Mucinum

Bisacodyl

Bisacodyl is reported as an ingredient of Mucinum in the following countries:

• Belgium

International Drug Name Search

Apo-Sucralfate

Apo-Sucralfate may be available in the countries listed below.

Ingredient matches for Apo-Sucralfate

Sucralfate

Sucralfate is reported as an ingredient of Apo-Sucralfate in the following countries:

• Canada


• Hong Kong


• Singapore

International Drug Name Search

Kenesil

Kenesil may be available in the countries listed below.

Ingredient matches for Kenesil

Nimodipine

Nimodipine is reported as an ingredient of Kenesil in the following countries:

• Spain

International Drug Name Search

Excenel

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Excenel

Ceftiofur

Ceftiofur is reported as an ingredient of Excenel in the following countries:

• Poland

Ceftiofur hydrochloride (a derivative of Ceftiofur) is reported as an ingredient of Excenel in the following countries:

• Australia


• Belgium


• France


• Germany


• Ireland


• Italy


• Netherlands


• New Zealand


• South Africa


• Switzerland


• United Kingdom


• United States

Ceftiofur sodium salt (a derivative of Ceftiofur) is reported as an ingredient of Excenel in the following countries:

• Australia


• Austria


• Belgium


• France


• Germany


• Ireland


• Italy


• Luxembourg


• Netherlands


• New Zealand


• South Africa


• Sweden


• Switzerland


• United Kingdom

International Drug Name Search

Famec

Famec may be available in the countries listed below.

Ingredient matches for Famec

Famotidine

Famotidine is reported as an ingredient of Famec in the following countries:

• Turkey

International Drug Name Search

Celestone Chronodose

Celestone Chronodose may be available in the countries listed below.

Ingredient matches for Celestone Chronodose

Betamethasone

Betamethasone 21-acetate and 21-(disodium phosphate) (a derivative of Betamethasone) is reported as an ingredient of Celestone Chronodose in the following countries:

• Australia


• Belgium


• Finland


• Greece


• Israel


• Netherlands


• New Zealand


• Switzerland

International Drug Name Search

Isosorbidemononitraat ratiopharm

Isosorbidemononitraat ratiopharm may be available in the countries listed below.

Ingredient matches for Isosorbidemononitraat ratiopharm

Isosorbide Mononitrate

Isosorbide Mononitrate is reported as an ingredient of Isosorbidemononitraat ratiopharm in the following countries:

• Netherlands

International Drug Name Search

Celestone S Coloide

Celestone S Coloide may be available in the countries listed below.

Ingredient matches for Celestone S Coloide

Betamethasone

Betamethasone is reported as an ingredient of Celestone S Coloide in the following countries:

• Spain

Sulfacetamide Sodium

Sulfacetamide sodium salt (a derivative of Sulfacetamide) is reported as an ingredient of Celestone S Coloide in the following countries:

• Spain

International Drug Name Search

PMS-Simvastatin

PMS-Simvastatin may be available in the countries listed below.

Ingredient matches for PMS-Simvastatin

Simvastatin

Simvastatin is reported as an ingredient of PMS-Simvastatin in the following countries:

• Canada

International Drug Name Search

Farnitran

Farnitran may be available in the countries listed below.

Ingredient matches for Farnitran

Nitrendipine

Nitrendipine is reported as an ingredient of Farnitran in the following countries:

• Portugal

International Drug Name Search

Tanflex

Tanflex may be available in the countries listed below.

Ingredient matches for Tanflex

Benzydamine

Benzydamine hydrochloride (a derivative of Benzydamine) is reported as an ingredient of Tanflex in the following countries:

• Indonesia


• Turkey

International Drug Name Search

Floracid

Floracid may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Floracid

Levofloxacin

Levofloxacin is reported as an ingredient of Floracid in the following countries:

• Russian Federation

Sulfadiazine

Sulfadiazine is reported as an ingredient of Floracid in the following countries:

• Germany

Trimethoprim

Trimethoprim is reported as an ingredient of Floracid in the following countries:

• Germany

International Drug Name Search

Renagel

In the US, Renagel (sevelamer systemic) is a member of the drug class chelating agents and is used to treat Hyperphosphatemia of Renal Failure.

US matches:

• Renagel

UK matches:

• Renagel 800 mg film-coated tablets
• Renagel 800 mg film-coated tablets (SPC)

Ingredient matches for Renagel

Sevelamer

Sevelamer is reported as an ingredient of Renagel in the following countries:

• Austria


• Belgium


• Croatia (Hrvatska)


• France


• Germany


• Italy


• Latvia


• Norway


• Portugal


• Sweden


• Switzerland


• Turkey


• United Kingdom

Sevelamer hydrochloride (a derivative of Sevelamer) is reported as an ingredient of Renagel in the following countries:

• Argentina


• Australia


• Canada


• Czech Republic


• Denmark


• Finland


• Greece


• Hungary


• Iceland


• Ireland


• Israel


• Japan


• Luxembourg


• Netherlands


• New Zealand


• Oman


• Romania


• Serbia


• Slovenia


• Spain


• Taiwan


• United States

International Drug Name Search

Glossary

SPC	Summary of Product Characteristics (UK)

Click for further information on drug naming conventions and International Nonproprietary Names.

Alamycin Spray

Alamycin Spray may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Alamycin Spray

Oxytetracycline

Oxytetracycline hydrochloride (a derivative of Oxytetracycline) is reported as an ingredient of Alamycin Spray in the following countries:

• Switzerland

International Drug Name Search

Funide

Funide may be available in the countries listed below.

Ingredient matches for Funide

Terbinafine

Terbinafine is reported as an ingredient of Funide in the following countries:

• Colombia

Terbinafine hydrochloride (a derivative of Terbinafine) is reported as an ingredient of Funide in the following countries:

• Peru

International Drug Name Search

Calcio Gluconato Bioindustria

Calcio Gluconato Bioindustria may be available in the countries listed below.

Ingredient matches for Calcio Gluconato Bioindustria

Calcium Gluconate

Calcium Gluconate is reported as an ingredient of Calcio Gluconato Bioindustria in the following countries:

• Italy

International Drug Name Search

Ampicillan

Ampicillan may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Ampicillan

Ampicillin

Ampicillin trihydrate (a derivative of Ampicillin) is reported as an ingredient of Ampicillan in the following countries:

• Netherlands

International Drug Name Search

Likmoss

Likmoss may be available in the countries listed below.

Ingredient matches for Likmoss

Clarithromycin

Clarithromycin is reported as an ingredient of Likmoss in the following countries:

• Japan

International Drug Name Search

Cyclimycin

Cyclimycin may be available in the countries listed below.

Ingredient matches for Cyclimycin

Minocycline

Minocycline is reported as an ingredient of Cyclimycin in the following countries:

• South Africa

International Drug Name Search

Clomipramine HCl PCH

Clomipramine HCl PCH may be available in the countries listed below.

Ingredient matches for Clomipramine HCl PCH

Clomipramine

Clomipramine hydrochloride (a derivative of Clomipramine) is reported as an ingredient of Clomipramine HCl PCH in the following countries:

• Netherlands

International Drug Name Search

Bupropion Hydrochloride GSK

Bupropion Hydrochloride GSK may be available in the countries listed below.

Ingredient matches for Bupropion Hydrochloride GSK

Bupropion

Bupropion hydrochloride (a derivative of Bupropion) is reported as an ingredient of Bupropion Hydrochloride GSK in the following countries:

• Latvia

International Drug Name Search

Carbastat

In the US, Carbastat (carbachol ophthalmic) is a member of the drug class ophthalmic glaucoma agents and is used to treat Intraocular Hypertension and Production of Miosis.

US matches:

• Carbastat Ocular


• Carbastat

Ingredient matches for Carbastat

Carbachol

Carbachol is reported as an ingredient of Carbastat in the following countries:

• United States

International Drug Name Search

Ibuprofen Heumann

Ibuprofen Heumann may be available in the countries listed below.

Ingredient matches for Ibuprofen Heumann

Ibuprofen

Ibuprofen is reported as an ingredient of Ibuprofen Heumann in the following countries:

• Germany

International Drug Name Search

Triosules

Triosules may be available in the countries listed below.

Ingredient matches for Triosules

Fluorouracil

Fluorouracil is reported as an ingredient of Triosules in the following countries:

• Argentina

International Drug Name Search

Cipro

In the US, Cipro (ciprofloxacin systemic) is a member of the drug class quinolones and is used to treat Anthrax, Anthrax Prophylaxis, Bacteremia, Bacterial Infection, Bladder Infection, Bone infection, Bronchitis, Chancroid, Cholera, Crohn's Disease, Cutaneous Bacillus anthracis, Diverticulitis, Febrile Neutropenia, Gonococcal Infection - Disseminated, Gonococcal Infection - Uncomplicated, Granuloma Inguinale, Infection Prophylaxis, Infectious Diarrhea, Intraabdominal Infection, Joint Infection, Kidney Infections, Meningococcal Meningitis Prophylaxis, Mycobacterium avium-intracellulare - Treatment, Nosocomial Pneumonia, Peritonitis, Plague, Pneumonia, Pneumonia with Cystic Fibrosis, Prostatitis, Rabbit Fever, Salmonella Enteric Fever, Salmonella Gastroenteritis, Shigellosis, Sinusitis, Skin Infection, Traveler's Diarrhea, Tuberculosis - Active, Typhoid Fever and Urinary Tract Infection.

US matches:

• Cipro


• Cipro HC Otic


• Cipro I.V.


• Cipro Suspension


• Cipro XR Extended-Release Tablets


• Cipro HC


• Cipro XR


• Cipro IV


• Cipro Iv Minibags

Ingredient matches for Cipro

Ciprofloxacin

Ciprofloxacin is reported as an ingredient of Cipro in the following countries:

• Argentina


• Colombia


• Peru


• Tunisia


• United States

Ciprofloxacin hydrochloride (a derivative of Ciprofloxacin) is reported as an ingredient of Cipro in the following countries:

• Argentina


• Brazil


• Canada


• Colombia


• Georgia


• Turkey


• United States

Ciprofloxacin lactate (a derivative of Ciprofloxacin) is reported as an ingredient of Cipro in the following countries:

• Colombia


• United States

International Drug Name Search

Amoxi-Tablinen

Amoxi-Tablinen may be available in the countries listed below.

Ingredient matches for Amoxi-Tablinen

Amoxicillin

Amoxicillin trihydrate (a derivative of Amoxicillin) is reported as an ingredient of Amoxi-Tablinen in the following countries:

• Germany

International Drug Name Search

Traital

Traital may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Traital

Aluminium Salicylate

Aluminium Salicylate is reported as an ingredient of Traital in the following countries:

• France

Neomycin

Neomycin sulfate (a derivative of Neomycin) is reported as an ingredient of Traital in the following countries:

• France

International Drug Name Search

Aluminium Sulphate

Scheme

Ph. Eur.

CAS registry number (Chemical Abstracts Service)

0010043-01-3

Chemical Formula

Al2-O12-S3

Molecular Weight

342

Therapeutic Categories

Astringent agent

Antiinfective

Dermatological agent: Antiperspirant

Chemical Names

Aluminium Sulfate (anhydrous)

Aluminium Sulphate (anhydrous)

Dialuminiumtrisulfat (IUPAC)

Foreign Names

• Aluminii sulfas (Latin)
• Aluminiumsulfat (German)
• Aluminium, sulfate d' (French)

Generic Names

• Aluminium sulfuricum (IS)
• Aluminium sulphate (IS)
• Aluminium trisulfate (IS)
• Alunogenite (IS)
• Dialuminium sulfate (IS)
• Dialuminium sulphate (IS)
• Dialuminium trisulfate (IS)
• E520 (IS)
• Nalco 7530 (IS)
• Sulfatodialuminium disulfate (IS)
• Sulfuric acid, aluminium salt (IS: 3:2)
• Aluminii sulfas (PH: Ph. Eur. 6, Ph. Int. 4)
• Aluminium Sulphate (PH: BP 2010, Ph. Eur. 6)
• Aluminum Sulfate (PH: USP 32, Ph. Int. 4)

Brand Names

• Stingose
  Hamilton, Hong Kong; Pfizer Consumer Health, Australia

International Drug Name Search

Glossary

IUPAC	International Union of Pure and Applied Chemistry
IS	Inofficial Synonym
PH	Pharmacopoeia Name
Ph. Eur.	European Pharmacopoeia

Click for further information on drug naming conventions and International Nonproprietary Names.

Fentanyl Sandoz

Fentanyl Sandoz may be available in the countries listed below.

Ingredient matches for Fentanyl Sandoz

Fentanyl

Fentanyl is reported as an ingredient of Fentanyl Sandoz in the following countries:

• Austria


• Belgium


• Estonia


• France


• Germany


• Greece


• Hungary


• Latvia


• Lithuania


• Netherlands


• Slovakia


• Switzerland

International Drug Name Search

Emedrin N

Emedrin N may be available in the countries listed below.

Ingredient matches for Emedrin N

Dextromethorphan

Dextromethorphan hydrobromide (a derivative of Dextromethorphan) is reported as an ingredient of Emedrin N in the following countries:

• Switzerland

International Drug Name Search

Gericin

Gericin may be available in the countries listed below.

Ingredient matches for Gericin

Nitrendipine

Nitrendipine is reported as an ingredient of Gericin in the following countries:

• Spain

International Drug Name Search

Amisulprida Arafarm Group

Amisulprida Arafarm Group may be available in the countries listed below.

Ingredient matches for Amisulprida Arafarm Group

Amisulpride

Amisulpride is reported as an ingredient of Amisulprida Arafarm Group in the following countries:

• Spain

International Drug Name Search

Flurinol

Flurinol may be available in the countries listed below.

Ingredient matches for Flurinol

Epinastine

Epinastine hydrochloride (a derivative of Epinastine) is reported as an ingredient of Flurinol in the following countries:

• Argentina


• Chile


• Colombia


• Costa Rica


• Dominican Republic


• El Salvador


• Guatemala


• Honduras


• Mexico


• Nicaragua


• Panama


• Peru


• Venezuela

International Drug Name Search

Fluor-Vigantoletten

Fluor-Vigantoletten may be available in the countries listed below.

Ingredient matches for Fluor-Vigantoletten

Colecalciferol

Colecalciferol is reported as an ingredient of Fluor-Vigantoletten in the following countries:

• Germany

Sodium Fluoride

Sodium Fluoride is reported as an ingredient of Fluor-Vigantoletten in the following countries:

• Germany

International Drug Name Search

Bisoprolol Jaba

Bisoprolol Jaba may be available in the countries listed below.

Ingredient matches for Bisoprolol Jaba

Bisoprolol

Bisoprolol is reported as an ingredient of Bisoprolol Jaba in the following countries:

• Portugal

International Drug Name Search

Pridimet

Pridimet may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Pridimet

Sulfadimethoxine

Sulfadimethoxine sodium (a derivative of Sulfadimethoxine) is reported as an ingredient of Pridimet in the following countries:

• Italy

Trimethoprim

Trimethoprim is reported as an ingredient of Pridimet in the following countries:

• Italy

International Drug Name Search

Aciclomed

Aciclomed may be available in the countries listed below.

Ingredient matches for Aciclomed

Acyclovir

Aciclovir is reported as an ingredient of Aciclomed in the following countries:

• Belgium

International Drug Name Search

Floximax

Floximax may be available in the countries listed below.

Ingredient matches for Floximax

Levofloxacin

Levofloxacin is reported as an ingredient of Floximax in the following countries:

• Ecuador

International Drug Name Search

Gibonz

Gibonz may be available in the countries listed below.

Ingredient matches for Gibonz

Tizanidine

Tizanidine hydrochloride (a derivative of Tizanidine) is reported as an ingredient of Gibonz in the following countries:

• Japan

International Drug Name Search

Glipal

Glipal may be available in the countries listed below.

Ingredient matches for Glipal

Simvastatin

Simvastatin is reported as an ingredient of Glipal in the following countries:

• Greece

International Drug Name Search

Tansulosina Baldacci

Tansulosina Baldacci may be available in the countries listed below.

Ingredient matches for Tansulosina Baldacci

Tamsulosin

Tamsulosin is reported as an ingredient of Tansulosina Baldacci in the following countries:

• Portugal

International Drug Name Search

Calcium Leucovorin

Calcium Leucovorin may be available in the countries listed below.

Ingredient matches for Calcium Leucovorin

Calcium Folinate

Calcium Folinate is reported as an ingredient of Calcium Leucovorin in the following countries:

• India


• Ireland


• Oman


• Turkey

International Drug Name Search

Troxerutin MK

Troxerutin MK may be available in the countries listed below.

Ingredient matches for Troxerutin MK

Troxerutin

Troxerutin is reported as an ingredient of Troxerutin MK in the following countries:

• Romania

International Drug Name Search

Cotrim forte Heumann

Cotrim forte Heumann may be available in the countries listed below.

Ingredient matches for Cotrim forte Heumann

Trimethoprim

Trimethoprim is reported as an ingredient of Cotrim forte Heumann in the following countries:

• Germany

International Drug Name Search

Pargeverine

Scheme

Rec.INN

CAS registry number (Chemical Abstracts Service)

0013479-13-5

Chemical Formula

C21-H23-N-O3

Molecular Weight

337

Therapeutic Category

Antispasmodic agent

Chemical Name

Benzeneacetic acid, α-phenyl-α-(2-propynyloxy)-, 2-(dimethylamino)ethyl ester

Foreign Names

• Pargeverinum (Latin)
• Pargeverin (German)
• Pargévérine (French)
• Pargeverina (Spanish)

Generic Names

• BE 50 (IS)
• Propinox (IS)
• R 164 (IS)
• Propinox hydrochloride (IS)

Brand Names

• Bevitex
  Prater, Chile



• Daprinol
  Infaca, Dominican Republic



• Dipinox
  Life, Ecuador



• Espasmokolic (Pargeverine and Clonixin)
  Sherfarma, Peru



• Espasmosedil (Pargeverine and Clonixin)
  Markos, Peru



• Nova
  Lazar, Argentina



• Plidan
  Roemmers, Peru; Roemmers, Venezuela



• Plidán
  Siegfried, Mexico



• Sernox
  Paill, El Salvador



• Sertal
  Roemmers, Argentina



• Vagopax
  Jaba, Portugal



• Viadil
  Pharma Investi, Chile



• Viplan
  Medipharm, Chile



• Viproxil
  Andromaco, Chile

International Drug Name Search

Glossary

IS	Inofficial Synonym
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)

Click for further information on drug naming conventions and International Nonproprietary Names.